Targeted Degradation of the Cyclin-Dependent Kinase Inhibitor ICK4/KRP6 by RING-Type E3 Ligases Is Essential for Mitotic Cell Cycle Progression during Arabidopsis Gametogenesis W OA
نویسندگان
چکیده
Jingjing Liu,a Yiyue Zhang,b Genji Qin,a Tomohiko Tsuge,c Norihiro Sakaguchi,d Guo Luo,a Kangtai Sun,a Dongqiao Shi,b Shiori Aki,c Nuoyan Zheng,b Takashi Aoyama,c Atsuhiro Oka,c Weicai Yang,b Masaaki Umeda,d Qi Xie,b Hongya Gu,a,e and Li-Jia Qua,e,1 a National Laboratory for Protein Engineering and Plant Genetic Engineering, Peking-Yale Joint Research Center for Plant Molecular Genetics and AgroBiotechnology, College of Life Sciences, Peking University, Beijing 100871, People’s Republic of China b Institute of Genetics and Developmental Biology, Beijing 100101, People’s Republic of China c Institute for Chemical Research, Kyoto University, Gokasho Uji, Kyoto 611-0011, Japan d Graduate School of Biological Sciences, Nara Institute of Science and Technology, Takayama 8916-5 Ikoma, Nara 630-0101, Japan e National Plant Gene Research Center (Beijing), Beijing 100101, People’s Republic of China
منابع مشابه
Targeted degradation of the cyclin-dependent kinase inhibitor ICK4/KRP6 by RING-type E3 ligases is essential for mitotic cell cycle progression during Arabidopsis gametogenesis.
Following meiosis, plant gametophytes develop through two or three rounds of mitosis. Although the ontogeny of gametophyte development has been defined in Arabidopsis thaliana, the molecular mechanisms regulating mitotic cell cycle progression are not well understood. Here, we report that RING-H2 group F 1a (RHF1a) and RHF2a, two RING-finger E3 ligases, play an important role in Arabidopsis gam...
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In Arabidopsis thaliana, seven cyclin-dependent kinase (CDK) inhibitors have been identified, designated interactors of CDKs or Kip-related proteins (KRPs). Here, the function of KRP6 was investigated during cell cycle progression in roots infected by plant-parasitic root-knot nematodes. Contrary to expectations, analysis of Meloidogyne incognita-induced galls of KRP6-overexpressing lines revea...
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In animals and fungi, a group of proteins called the cyclin-dependent kinase inhibitors play a key role in cell cycle regulation. However, comparatively little is known about the role of these proteins in plant cell cycle regulation. To gain insight into the mechanisms by which the plant cell cycle is regulated, we studied the cyclin-dependent kinase inhibitor KRP1 in Arabidopsis. KRP1 interact...
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The regulated oscillation of protein expression is an essential mechanism of cell cycle control. The SCF class of E3 ubiquitin ligases is involved in this process by targeting cell cycle regulatory proteins for degradation by the proteasome, with the F-box subunit of the SCF specifically recruiting a given substrate to the SCF core. Here we identify NIPA (nuclear interaction partner of ALK) as ...
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